DESIGN AND OPTIMIZATION OF FLUCONAZOLE-LOADED PHARMACOSOME GEL FOR ENHANCING TRANSDERMAL PERMEATION AND TREATING FUNGAL INFECTIONS THROUGH BOX-BEHNKEN DESIGN

Objective: The objective of the selected study was to develop and statistically optimize fluconazole (drug) loaded pharmacosomes (carrier) enhance transdermal permeation by incorporating into gel base treat fungal infections selecting Box-Behnken model. Methods: Fluconazole is an antifungal drug which belongs BCS class-II with high permeability choice for topical delivery. In study, levels lecithin (lipid), dichloromethane DMSO are as independent variables were varied influence on particle size, % entrapment efficiency in vitro release dependent variables. Factorial designs through software Design expert version 13 (Box-Behnken design) applied this optimization process carried out using desirability plots point prediction techniques. Results: Results application a design shows that optimized drug-loaded vesicle size 158.87±0.56 nm predicted zeta potential of-30.6mV indicating good stability formulation, 90.6±1.12% 97.59±1.84% respectively. formulation compared marketed formulation. All evaluation parameters confirmed physical mixture excipients compatible without any interactions. Conclusion: Through obtained results, it’s concluded that; variable plays crucial role optimizing Study data provided strong evidence vesicular factorial can be potentially useful carrier loading category enhancing